Pdf Population Pharmacokinetics Of Orally Administered Clindamycin To

Pdf Population Pharmacokinetics Of Orally Administered Clindamycin To In the present study, we have developed a population pharmacokinetic model for clindamycin used in adults treated for bone and joint infections to study the influence of covariates (body weight, age, co treatments) on pharmacokinetics. the main goal was then to optimize the dose of clindamycin given to patients with osteomyelitis. This study was performed to describe clindamycin, administered either orally or intravenously, concentration time courses to patients with osteomyelitis, to study the effects of different covariates on clindamycin pharmacokinetics and to simulate an optimized administration scheme. methods clindamycin concentrations were measured in 50 patients.

Pdf Population Pharmacokinetics Of Cc 122 Methods: clindamycin concentrations were measured in 50 patients. a total of 122 plasma concentrations were available (58 from oral administration and 64 from i.v. infusion). a population pharmacokinetic model was developed with monolix 4 software. results: a one compartment model adequately described the data. clindamycin clearance increased. A population pk model of clindamycin orally administered to patients with prosthetic joint infections (pjis) was developed using nonmem 7.5. monte carlo simulations were run to determine the probability of obtaining bone clindamycin concentrations equal to at least the mic or four times the mic for several mic values and dosing regimens. The population pharmacokinetics of clindamycin have been previously described following both oral and intravenous administration (bouazza et al. 2012). the drug has an average plasma elimination. The current recommendation of 600 mg three times daily seems to be effective up to 75’kg but the dose should be raised to 900’mg three once daily thereafter. aims this study was performed to describe clindamycin, administered either orally or intravenously, concentration time courses to patients with osteomyelitis, to study the effects of different covariates on clindamycin.

Population Pharmacokinetics Of Clindamycin Orally And Intravenously The population pharmacokinetics of clindamycin have been previously described following both oral and intravenous administration (bouazza et al. 2012). the drug has an average plasma elimination. The current recommendation of 600 mg three times daily seems to be effective up to 75’kg but the dose should be raised to 900’mg three once daily thereafter. aims this study was performed to describe clindamycin, administered either orally or intravenously, concentration time courses to patients with osteomyelitis, to study the effects of different covariates on clindamycin. Doi: 10.1111 j.1365 2125.2012.04292.x corpus id: 205256155; population pharmacokinetics of clindamycin orally and intravenously administered in patients with osteomyelitis. @article{bouazza2012populationpo, title={population pharmacokinetics of clindamycin orally and intravenously administered in patients with osteomyelitis.}, author={na{\"i}m bouazza and vincent pestre and vincent jullien and. A population pk model of clindamycin orally administered to patients with prosthetic joint infections (pjis) was developed using nonmem 7.5. monte carlo simulations were run to determine the probability of obtaining bone clindamycin concentrations equal to at least the mic or four times the mic for several mic values and dosing regimens. one hundred and forty plasma concentrations.